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KMID : 0191120000150040449
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Journal of Korean Medical Science
2000 Volume.15 No. 4 p.449 ~ p.451
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Association of the dopamine transporter gene with Parkinson´s disease in Korean patients
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Kim JW
Kim DH/Kim SH/Cha JK
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Abstract
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Dopamine transporters (DAT) uptake neurotoxic substances such as 1-methyl-4-phenylpyridinium (MPP+) in the dopaminergic nerve terminals and may confer susceptibility to cytotoxic effects of neurotoxic substance. The association of a variable number tandem repeat polymorphism in the DAT gene with Parkinson's disease (PD) in a Korean population was studied. The 10-copy allele was the most common, accounting for 77.2% and 81.6% of alleles in PD patients and control subjects, respectively. The rare 11-copy allele was more common in the patients (odds ratio = 2.5, 95% confidence interval = 1.1-5.7, p<0.02). It is suggested that the 11-copy allele of the DAT gene may confer susceptibility to PD for some patients in Korea.
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KEYWORD
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